Automated Solutions for Cell Line Development
Your Guide to Workflow Intelligence
Product Solutions
Biomek i7 Automated Workstation
Improve procedural ELISA, achieve single cell suspension reliably, simplify transfection optimization, and adapt basic cell culture workflows.
- Extend production scale and centralize operations
- Leverage dual-arm pipetting
- Flexibility with reagent and media mixing, and cell passaging and plating
- Improve efficiency by directly integrating required components
- Simplify serial dilutions with built-in spanning transfer system
- Improve analysis efficiency with sample and data tracking*
- Take control of multi-day planning*
- Monitor progress with platform status light
- Remote system monitoring using on-deck cameras
*Possible through optional software packages DART and SAMI.
Orbital Shaker
Promote cell health with user-definable and reliable agitation of microplates, cultured cells, or general vortexing.- Smooth and continuous motion, enabling nutrient diffusion without splashing
- Timed oribtal and pulse shaking
- Ramped acceleration/deceleration
- Shaking speed ranges from 100 rpm to 1800 rpm
- Space saving
- Easily integrated with Biomek i7
- Increases experimental flexibility
Reagent Dispensers
Accelerate assay-specific or maintenance laboratory protocols with automated, precise dispensing. Ensure the accuracy of reagent dispense volumes.- Simplify workflows
- Dispense a wide range of volumes
- Minimize contamination
- Interchangeable dispensing heads available
- Increase accuracy
- Superior mixing
- Reduce air bubble formation
- Integrates with Biomek i7
- Flexibility to configure reagent containers of wide-ranging volumes
Automated Labware Positioners (ALPs)
Workstation-integrated and interchangeable components that perform specific tasks. ALPs make it possible to configure the platform for accommodation of a wide range of applications.Peltier
- Shaking model shakes microplates at speeds ranging from 100 rpm to 1400 rpm
- Temperature control capable
Tilting ALP
- Controlled and gentle media exchange
- Media is removed from edge of well without disturbing adherent cells
Incubator
An incubator provides a consistent environment for the housing of growing cell cultures and for the temporary incubation of cells underdoing experimental assays.- Temperature can range from 4° C to 70° C, with a relative high humidity (RH) of up to 98% stable CO2 conditions, and shaking
- Mammalian cell conditions: 37° C, 95% RH, and 5% CO2
- A Biomek i7 integration with an incubator eliminates recovery loss and reduces assay variance
- Increase throughput
- Streamline long-term cell culture processes
- Eliminate manual, repeated accessing of cells
Vi-CELL BLU
Eliminate human error and user bias when counting cells and determining viability.- Automated solution for Trypan Blue viability assays
- Analyze mammalian, insect, and yeast cell types (2–70 microns)
- Clumpy samples can be differentiated in number and viability
- Quickly and reliably assess cell shape, size, growth rate, and doubling time
- Enhance statistical reliability
- Convenient reagent kit, concentration control, and sample cups
- Viable cells are outlined in green and nonviable in red:
CloneSelect™ Imager
Rapidly and objectively monitor cell growth, verify cell line monoclonality, and normalize measurements specific to cell productivity.
- Ultra-fast benchtop imaging system for:
- Confluence measurement
- Growth curve generation
- Cell number estimation
- Monoclonality verification
- Colony forming assays
- Cytotoxicity assays
- Cell migration assays
- Consistent results in less time
- Saves all images and generated data
- Integrates with Biomek i7 workstation
“CloneSelect Imager has become an essential system for verification of monoclonality within our cell line development workflow.”
− Dr. Howard Clarke, Process Development, CMC ICOS Biologics Inc., USA
ValitaTiter
ValitaTiter is a plate based, 96 and 384-well assay that offers a rapid, cost effective way to measure IgG.
Robotic Arm
Offers dependable precision and flexibility that not only increases useable workspace, but reliably operates around the clock to eliminate human variability.
- Multiple axis points can reach peripheral equipment
- Walk away capability increases personnel productivity
- Accelerates time to results
- Enhance data reproducibility
- Improve laboratory ergonomics
- Integrates with Biomek i7
Capper/Decapper
Hands-free automated capping and decapping technology ensures sample protection, wholeness, and quality.
- Cap tubes to optimal torque
- Reliably increase throughput
- Improve laboratory ergonomics
- Benchtop or integrated use
- Internal controls prevent contamination and debris introduction
Robotic Shuttle
Controlled robotic plate management with a customizable conveyor track assists with handling consistency and eliminates human-induced accidents.
- Conveyor transports plates from location the Biomek deck to off deck components within the workstation
- Allows for simultaneous transports on and off deck for maximum efficiency
- Streamlines workflow for maximum productivity
Avanti JXN
High-Speed Centrifuge
Enhance isolation and purification workflows for a variety of bioproduction needs.
- Friction reduction system (FRS) for quicker, quieter, and cooler runs
- Shorter cycle times with high-torque and switched reluctance (SR) drive cycle
- Remote run setup and monitoring
- Hands-free door operation
- Track and control usage and samples
- Efficient, safe workflow matches industry compliance
Workflow Solutions
Learn about the solutions for each critical step of the process of developing a mammalian cell line for recombinant protein manufacturing using a methotrexate (MTX) amplification system, one of many integrated transfection methods by Beckman Coulter.
Automation can increase efficiency and consistency in selecting high producing cells with desired Critical Quality Attributes.
Cell Line Engineering
Optimal host cell transfection is dependent on cell health, degree of confluency, DNA quality and quantity, number of passages, contamination, and transfection reagent or method. OUR SOLUTIONS:
Biomek i7 Automated Workstation
- Preparation of transfection reagents, addition of expression plasmid and transfection reagents
- Cell plating, handling, and maintenance minimize human error, enhancing reproducibility and enabling continuous production
Vi-CELL BLU Cell Viability Analyzer
- Count and image cells
- Stain cells and measure viability
Reagent Dispenser
- Configure reagent containers of wide-ranging volumes
Robotic Arm
- Moves plates between workstation and analyzer
Cell Line Characterization
Select colonies by sub-cloning, which includes performing multiple rounds of serial dilution to identify the most stable and highest-producing single cell clone. This step is labor intensive and requires weeks to complete.
OUR SOLUTIONS:
CloneSelect™ Imager
- Verify monoclonality
- Optimize and monitor clonal outgrowth
Biomek i7 Automated Workstation
- Cell-plating, handling, maintenance, and hitpicking
Automated Labware Positioners (ALPs)
- Perform application-specific or general tasks to expedite protocols
Reagent Dispenser
- Configure to dispense reagents from different containers and wide-ranging volumes
Robotic Arm
- Moves plates to/from workstation, incubator*
Cell Line Characterization
Expand the clone producing your desired protein to begin the process development and optimization stage. Certifying clone productivity and quality is fundamental to efficient cell line scale up. Maintaining cell culture health and stable production are common pitfalls during this step. OUR SOLUTIONS:
Vi-CELL Cell Viability Analyzer
- Count and image cells
- Stain cells and measure viability
Biomek i7 Automated Workstation
- Hit picking and seeding
Robotic Arm
- Moves plates to/from workstation and analyzer
Robotic Shuttle
- Conveyor track eliminates human-induced mishaps during transport
- Speed and acceleration can be controlled to prevent splashing in larger-well plates
Avanti JXN High-Speed Centrifuge
- Isolate and purify products reliably and efficiently
Process Development
As you scale up, media optimization will enable maximize protein production. An ideal approach is using a factorial design of experiment (DOE), where a variety of media components are tested at different concentrations in combination with one another. Automation of DOE eliminates any sample preparation beyond an optional dilution step and the high throughput models can process up to 96 samples simultaneously.
OUR SOLUTIONS:
Biomek i7 Automated Workstation
- Tight control of media dispensing volumes
- Gentle cell handling through controlled speed prevents cell shearing and damage
- DOE optimization with multi-channel selection tip
ValitaTiter
- Measures IgG
CloneSelect™ Imager
- Monitor cell growth
Reagent Dispenser
- Configure reagent containers of wide-ranging volumes
Biomek Automated Workstations are not intended or validated for use in the diagnosis of disease or other conditions. Beckman Coulter Life Sciences genomic reagent kits are for research US only.
Helpful Links
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資料集
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アプリケーションノート
- フローサイトメトリーによる簡単な17 マーカー、 18カラーのヒト血液フェノタイピング
- 21 CFR Part 11 Data Integrity for On-line WFI Instruments
- 8011+ Reporting Standards Feature and Synopsis
- フローサイトメトリーを用いた海洋サンプル中植物プランクトンの正確な計数
- ファインバブルのサイズと粒子数を正確に測定
- Achieving Compliant Batch Release – Sterile Parenteral Quality Control
- 気中浮遊粒子のモニタリング:ISO21501-4校正のインパクト
- 分析における革命:次世代を担うOptima AUCの概要
- Multisizer 4eを用いた二枚貝の育成繁殖のための分析
- Automated 3D Cell Culture and Screening by Imaging and Flow Cytometry
- Automated Cell Transfection and Reporter Gene Assay
- Automated Cord Blood Cell Viability and Concentration Measurements Using the Vi‑CELL XR
- Automated Genomic Sample Prep Sample Quality Control
- Automated salt-assisted liquid-liquid extraction
- Automated Sample Preparation for the Monitoring of Pharmaceutical and Illicit Drugs by LC-MS/MS
- Biomek i7ハイブリッド・加圧インテグレーションシステムによる唾液中のカンナビノイド分析前処理の自動化
- Automated Transfection Methods
- Automated XTT Assay for Cell Viability Analysis
- Automating a Linear Density Gradient for Purification of a Protein:Ligand Complex
- Automating Biopharma Quality Control to Reduce Costs and Improve Data Integrity
- Automating Bradford Assays
- Automating Cell-Based Processes
- Automating Cell Line Development
- NGSワークフローの自動化比較:NGSライブラリ自動調製システム Biomek NGeniuSと従来型自動分注機 *
- NGS ライブラリ自動調製システム Biomek NGeniuS を用いた Illumina DNA Prep Kit の自動化
- 新機種Avanti J-15遠心機におけるサンプル保護の改善およびサンプル回収率の最大化
- 新機種Avanti J-15遠心機の短時間減速プロファイルによるワークフロー効率の向上
- Avanti JXNによるタンパク質精製ワークフロー
- バイオ医薬品の品質管理を目的として細胞カウントを自動化する際の注意点
- Beer, Evaluation of Final Product and Filtration Efficiency
- BiomekによるゲノムDNAライブラリ調製の自動化がもたらす研究の加速
- Biomek Automated NGS Solutions Accelerate Genomic Research
- Biomek i-Series Automated AmpliSeq for Illumina® Library Prep Kit
- Biomek i-Series Automated Beckman Coulter Agencourt RNAdvance Blood Kit
- Biomek i-Series Automated Beckman Coulter Agencourt RNAdvance Cell
- Biomek i-Series Automated Beckman Coulter Agencourt SPRIselect for DNA Size Selection
- Biomek i-Seriesを用いたAMPure XPによるPCR産物精製自動化システム
- Biomek i-Series Automated IDT® xGen Hybridization Capture of DNA libraries on Biomek i7 Hybrid Genomics Workstation
- Biomek i-Series Automated Illumina® Nextera XT DNA Library Prep Kit
- Biomek i-Series Automated Illumina TruSeq DNA PCR-Free Library Prep Kit
- Biomek i-Series Automated Illumina TruSeq® Nano DNA Library Prep Kit
- Biomek i-Series Automated Illumina TruSeq® Stranded mRNA Sample Preparation Kit Protocol
- Biomek i-Series Automated Illumina TruSeq® Stranded Total RNA Sample Preparation Kit Protocol
- Biomek i–Series Automated Illumina® TruSight Tumor 170 32 Sample Method
- Biomek i-Series Automated KAPA HyperPrep and HyperPlus Workflows
- Biomek i-Series Automated New England Biolabs NEBNext® Ultra IITM DNA Library Prep Kit
- Biomek i-Series Automated SurePlex PCR and VeriSeq PGS Library Prep for Illumina®
- Biomek i-Series Automation of the Beckman Coulter Agencourt DNAdvance Genomic DNA isolation Kit
- Biomek i-Series Automation of the Beckman Coulter GenFind V3 Blood and Serum DNA Isolation Kit
- Biomek i-Series Automation of the Apostle MiniMax™ High Efficiency cfDNA Isolation Kit
- 超遠心機および自動分注装置を用いた カーボンナノチューブの調製・精製と 分析用超遠心システムによる解析
- 生死細胞オートアナライザーVi–CELL BLUの計数性能評価
- 高速培地環境分析装置 Vi-CELL MetaFLEXによる細胞培養モニタリング
- Viability Assessment of Cell Cultures Using the CytoFLEX
- Cell Line Development – Data Handling
- Cell Line Development – Limiting Dilution
- Cell Line Development – Selection and Enrichment
- コールター原理を用いた細胞分析
- cfDNA Extraction Efficiency Affects NGS Data
- Changes to GMP Force Cleanroom Re-Classifications
- 超遠心分析を用いたバイオ医薬品インスリンのキャラクタリゼーション
- MET ONE HHPC 6+を用いた小型クリーンルームの空気清浄度クラス分類
- ハンドヘルド型気中パーティクルカウンターで行う クリーンキャビネットの定期的な評価
- FDA 21CFR Part11 データインテグリティガイダンスに基づくクリーンルームの日常的な環境モニタリング
- Comparing Data Quality & Optical Resolution of the Next Generation Optima AUC to the Proven ProteomeLab on a Model Protein System
- MET ONE 3400によるISO14644-3に基づいたクリーンルーム回復性能試験の実施
- 96ウェルプレートを利用して細胞の計数条件を決める有効な方法
- Consistent Cell Maintenance and Plating through Automation
- Control Standards and Method Recommendations for the LS 13 320 XR
- Counting Efficiency: MET ONE Air Particle Counters and Compliance to ISO-21501
- Critical Particle Size Distribution for Cement using Laser Diffraction
- フローサイトメトリーハイパラメータ(高次元)データでのマシンラーニングアルゴリズムを用いた解析・可視化 -CytoFLEX LX 20カラーパネルでの例-
- Detecting and counting bacteria with the CytoFLEX research flow cytometer: II-Characterization of a variety of gram-positive bacteria
- Detecting Moisture in Hydraulic Fluid, Oil and Fuels
- 半導体封止材のクラックを引き起こすシリカ中の粗大粒子の検出
- Multisizer 4eを用いたメッキ液中の異物検出
- Determination of Size and Concentration of Particles in Oils
- 沈殿および遠心分離を組み合わせたキットを使用しない効率的な核酸分離法
- dsDNA Quantification with the Echo 525 Liquid Handler for Miniaturized Reaction Volumes, Reduced Sample Input, and Cost Savings
- DURACloneのコンペンセーション設定
- Echo System-Enhanced SMART-Seq v2 for RNA Sequencing
- マルチプレックス全ゲノムシーケンシングおよびマイクロバイオームアプリケーションのためのIllumina Nextera XTライブラリ調製の効果的な微量化
- Efficient Factorial Optimization of Transfection Conditions
- ワクチン開発・製造を推し進める
- Enumeration And Size Distribution Of Yeast Cells In The Brewing Industry
- European Pharmacopoeia EP 2.2.44 and Total Organic Carbon
- 生死細胞オートアナライザー Vi–CELL BLUの機器間差評価テスト
- ベックマン・コールターの遠心機を使用したエクソソーム除去FBSの作製:コスト効果に優れた堅実な選択肢
- Flexible ELISA automation with the Biomek i5 Workstation
- 空気摩擦熱減少システム 高速冷却遠心機に搭載した優れた機能
- Fully-Automated Cellular Analysis by Flow Cytometry
- Biomek i7ハイブリッドワークステーションによる加圧式固相抽出を用いたベンゾジアゼピン分析前処理の自動化
- Biomek i7ハイブリッドワークステーションによる加圧式固相抽出を用いたカンナビノイド分析の自動化
- Biomek i7ハイブリッド・加圧インテグレーションシステムによるPhreeリン脂質除去カートリッジを用いたビタミンD測定前処理の自動化
- Biomek i7ハイブリッド・加圧・遠心分離インテグレーションシステムによるビタミンD測定前処理の自動化
- Get Control in GMP Environments
- Getting Started with Kaluza: Parameters
- g-Max:ベックマン・コールターの多機能な超遠心用製品群への性能追加
- 遠心機によるナノセルロースの分級
- 超遠心法によりナノ粒子を分級して 正確な粒子径を求める方法
- 超遠心分離法 / 動的光散乱法による 顔料インクの分級と粒子径測定
- HIAC Industrial – Our overview solution for fluid power testing for all applications
- A complete workflow for high-throughput isolation of DNA and RNA from FFPE samples using Formapure XL Total on the KingFisher™ Sample Purification System: an application for robust and scalable cancer research and biomarker discovery
- High-Throughput qPCR and RT-qPCR Workflows
- A Highly Consistent BCA Assay on Biomek i-Series
- A Highly Consistent Bradford Assay on Biomek i-Series
- A Highly Consistent Lowry Method on Biomek i-Series
- Highly Reproducible Automated Proteomics Sample Preparation on Biomek i-Series
- Cell Line Development – Hit Picking
- How to Use Violet Laser Side Scatter Detect Nanoparticle
- フローサイトメーターCytoFLEXを用いた、バイオレットレーザーの側方散乱光を利用してナノ粒子を検出する方法
- HIAC(ハイアック)システムでHRLDセンサーを使用する際の推奨ターボリューム設定
- Automating the Cell Line Development Workflow
- ICH Q2 – the Challenge of Measuring Total Organic Carbon in Modern Pharmaceutical Water Systems
- ICH Q2 – The Challenge of Measuring Total Organic Carbon in Modern Pharmaceutical Water Systems
- Illumina Nextera Flex for Enrichment on the Biomek i7 Hybrid Genomics Workstation
- Illumina TruSight Oncology 500 Automated on the Biomek NXᴾ Span-8 Genomics Workstation
- Importance of TOC measurement in WFI in light of European Pharmacopoeia change
- Integration of the Vi-CELL BLU Cell Viability Analyzer into the Sartorius Ambr® 250 High Throughput for automated determination of cell concentration and viability
- Temperature dependence of hydrodynamic radius of an intrinsically disordered protein measured in the Optima AUC analytical ultracentrifuge.
- Isolation of cell-free DNA (cfDNA) from plasma using Apostle MiniMax™ High Efficiency cfDNA Isolation kit— comparison of fully automated, semi-automated and manual workflow processing
- Issues with Testing Jet Fuels for Contamination
- 細胞代謝活性モニタリングにおける Vi-CELL MetaFLEXの有用性
- Linearity of BSA Using Absorbance & Interference Optics
- 光学式パーティクルカウンターにおける「Long Life Lasers(長寿命レーザー)」の検証
- LS 13 320 XR: Sample Preparation - How to measure success
- Particle Size Analysis Simple, Effective and Precise
- Beckman’s LS 13 320 XR Vs. Malvern Mastersizer
- 20カラー イムノタイピングデータのマシンラーニング アルゴリズムを用いた細胞サブセットの詳細解析
- Flow Cytometric Analysis of auto-fluorescent cells found in the marine demosponge Clathria prolifera
- Vi–CELL XRとVi–CELL BLUの 計数マッチング方法
- Recommended cleaning procedure for the exterior surface of the MET ONE 3400+
- MET ONE センサーの過酸化水素ガス(VHP)耐性
- 超遠心分離法による 金属コロイド精製と濃縮
- 密度勾配遠心法による 金ナノロッドの分離精製
- Vi-CELL BLUの計数値をVi-CELL XRに素早く一致させるための有効な方法
- High-throughput Miniaturization of Cytochrome P450 Time-dependent Inhibition Screening Using the Echo 525 Liquid Handler
- Miniaturization and Rapid Processing of TXTL Reactions Using Acoustic Liquid Handling
- Miniaturized Enzymatic Assays with Glycerol
- Miniaturized and High-Throughput Metabolic Stability Assay Enabled by the Echo Liquid Handler
- Miniaturized Multi-Piece DNA Assembly Using the Echo 525 Liquid Handler
- Miniaturized Sequencing Workflows for Microbiome and Metagenomic Studies
- Minimal Sample to Sample Carry Over with the HIAC 8011+
- ミネラルウォーター製造工程のばらつき最小化
- Modern Trends in Non‐Viable Particle Monitoring during Aseptic Processing
- Modular DNA Assembly of PIK3CA Using Acoustic Liquid Transfer in Nanoliter Volumes
- Multi-Wavelength Analytical Ultracentrifugation of Human Serum Albumin complexed with Porphyrin
- Nanoliter Scale DNA Assembly Utilizing the NEBuilder HiFi Cloning Kit with the Echo 525 Liquid Handler
- ナノ粒子複合材の粒子径測定 - 密度勾配超遠心法と動的光散乱法を用いて -
- Identification of Circulating Myeloid Cell Populations in NLRP3 Null Mice
- What to do now that ACFTD is discontinued
- Optimizing the HIAC 8011+ Particle Counter for Analyzing Viscous Fluids
- Optimizing the Multisizer 4e Coutler Counter for use with Small Apertures
- Optimizing Workflow Efficiency of Cleanroom Routine Environmental Monitoring
- Particle Counting in Mining Applications
- パーティクルカウンター資料集 高圧ガス配管内の清浄度測定- MET ONE 3400ガス校正オプションで ISO 14644の計測を簡単に -
- PCR Reaction Setup and AMPure XP Application
- PCR Reaction Setup Application
- 無菌医薬品製造区域の環境モニタリング
- 無菌医薬品製造のためのペーパーレスによる環境モニタリング
- Analysis of plant genome sizes using flow cytometry: a case study demonstrating dynamic range and measurement linearity
- Multisizer 4eによる脂肪細胞サイズの精密測定
- Principles of Continuous Flow Centrifugation
- Flow Cytometric Approach to Probiotic Cell Counting and Analysis
- Background Subtraction
- Calibrating the QbD1200 TOC Analyzer
- Detection Limit
- Inorganic Carbon Removal
- JP SDBS Validation
- Method Overview
- Overload Recovery
- QbD1200 Preparing Reagent Solution
- USP System Suitability
- Multisizer 4eを用いたブロッキング防止パウダーの粒子径の品質管理
- Quality Control Electronic Records for 21 CFR part 11 Compliance
- Using the Coulter Principle to Quantify Particles in an Electrolytic Solution for Copper Acid Plating
- A Rapid Flow Cytometry Data Analysis Workflow Using Machine Learning- Assisted Analysis to Facilitate Identifying Treatment- Induced Changes
- NGSライブラリ自動調製システム Biomek NGeniuS のエラー低減機能
- Root Cause Investigations for Pharmaceutical Water Systems
- Scalable Plasmid Purification using CosMCPrep
- Full Automation of the SISCAPA® Workflow using a Biomek NXP Laboratory Automation Workstation
- Biomek i7ハイブリッド・加圧インテグレーションシステムによる除タンパクカートリッジを用いたビタミンD測定前処理の自動化
- Vi–CELL XRとVi–CELL BLUとの仕様比較
- Specifying Non-Viable Particle Monitoring for Aseptic Processing
- ベックマン・コールターの装置を使用してエクソソームの分離および特性評価を行うための標準化・自動化されたアプローチ
- アコースティック分注による合成生物学の合理化
- Switching from Oil Testing to Water and back using the HIAC 8011+ and HIAC PODS+
- ドライ抗体試薬DURACloneを用いたフローサイトメーターCytoFLEXによるヒトT細胞サブセットの13カラー解析
- The Vi-CELL BLU cell viability analyzer: Cell counter performance comparison for CHO and HEK cells
- k-ファクタを利用したロータの効率比較
- Validation of On-line Total Organic Carbon Analysers for Release Testing Using ICH Q2
- 過酸化水素ガス滅菌によるVi–CELL BLUの性能評価
- Vesicle Flow Cytometry with the CytoFLEX
- Vi–CELL BLUの新機能、高速モード
- Vi-CELL BLU 規制への対応 – 21 CFR Part 11
- A workflow for medium-throughput isolation of cfDNA from plasma samples using Apostle MiniMax™ on the KingFisher™ Technology
- A fully automated plate-based optimization of fed-batch culture conditions for monoclonal antibody-producing CHO cell line
- A High-Throughput, Automated Screening Platform for IgG Quantification During Drug Discovery and Development
- Adaptive Laboratory Evolution of Pseudomonas putida in the RoboLector
- Aerobic cultivation of high-oxygen-demanding microorganisms in the BioLector XT microbioreactor
- BioLector マイクロバイオリアクターを使ったプロバイオティクス細菌の嫌気培養プロセス
- Assay Assembly for Miniaturized Quantitative PCR in a 384-well Format Using the Echo Liquid Handler
- Automated Research Flow Cytometry Workflow Using DURA Innovations Dry Reagent Technology with the *Biomek i7 Automated Workstation and *CytoFLEX LX Flow Cytometer
- Automating antibody titration using a CytoFLEX LX analyzer Integrated with a Biomek i7 Multichannel workstation and Cytobank streamlined data analysis
- Automated IDT Alt-R CRISPR/Cas9 Ribonucleoprotein Lipofection Using the Biomek i7 Hybrid Automated Workstation
- Automation of protein A ELISA Assays using Biomek i7 hybrid workstation
- Monitoring E. coli Cultures with the BioLector and Multisizer 4e Instruments
- Monitoring Yeast Cultures with the BioLector and Multisizer 4e instruments
- Biomek i7 Hybrid Automated KAPA mRNA HyperPrep Workflow
- Biomek i-Series Automated Promega Wizard MagneSil Tfx™ Plasmid Purification System
- Cultivation of suspended plant cells in the BioLector®
- チャネル数の異なるFCSファイルをRで書き換える方法
- Determination of cell death in the BioLector Microbioreactor
- DO-controlled fed-batch cultivation in the RoboLector®
- Screening of yeast-based nutrients for E. coli-based recombinant protein production using the RoboLector Platform
- E. coli fed-batch cultivation using the BioLector® Pro
- Echo System-Enhanced SMART-Seq v4 for RNA Sequencing
- Filling MicroClime Environmental Lids
- Fully Automated Peptide Desalting for Liquid Chromatography–Tandem Mass Spectrometry Analysis Using Beckman Coulter Biomek i7 Hybrid Workstation
- Getting Started with Kaluza: Data Scaling and Compensation Adjustment
- 環境モニタリングに最適なハンドヘルドパーティクルカウンターを選ぶためのシンプルガイド
- High throughput cultivation of the cellulolytic fungus Trichoderma reesei in the BioLector®
- High-throughput IgG quantitation platform for clone screening during drug discovery and development
- High-throughput Miniaturization of Cytochrome P450 Time-dependent Inhibition Screening Using the Echo 525 Liquid Handler
- Host Cell Residual DNA Testing in Reduced Volume qPCR Reactions Using Acoustic Liquid Handling
- Improved data quality of plate-based IgG quantification using Spark®’s enhanced optics
- Valita Titer 384ウェルプレートによるIgG定量スループットの向上
- Linearity of the Vi-CELL BLU Cell Counter and Analyzer
- Media optimization in the RoboLector platform for enhanced protein production using C. glutamicum
- MET ONE 3400+ LDAP & Active Directory connection Guide
- フローサイトメーターCytoFLEX Sでデザインしたパネルの セルソーターCytoFLEX SRTへの移行方法
- Miniaturization of an Epigenetic AlphaLISA Assay with the Echo Liquid Handler and the BMG LABTECH PHERAstar FS
- Miniaturization of Cytochrome P450 Time-dependent Inhibition Screening Using the Echo 555 Liquid Handler
- Miniaturized 16S rRNA Amplicon Sequencing with the Echo 525 Liquid Handler for Metagenomic and Microbiome Studies
- Miniaturized Enzo Life Sciences HDAC1 Fluor de Lys Assays Using an Echo Liquid Handler Integrated in an Access Laboratory Workstation
- Miniaturized EPIgeneous HTRF Assays Using the Echo Liquid Handler
- Miniaturized Gene Expression in as Little as 250 nL
- Miniaturized Genotyping Reactions Using the Echo Liquid Handler
- CytoFLEX SRTセルソーターによる ミックスモードソーティング
- Mode of operation of optical sensors for dissolved oxygen and pH value
- Nanoliter Scale High-Throughput Protein Crystallography Screening with the Echo Liquid Handler
- Nanoscale Sorting with the CytoFLEX SRT Cell Sorter
- Low-pH profiling in µL-scale to optimize protein production in H. polymorpha using the BioLector
- Optimized NGS Library Preparation with Acoustic Liquid Handling
- BioLector XT マイクロバイオリアクターを使った Chlorella vulgaris の光照射培養
- Plate Deposition Speed Comparison of Astrios and CytoFLEX SRT Cell Sorters
- Preparation of Mouse Plasma Microsamples for LC-MS/MS Analysis Using the Echo Liquid Handler
- Protocols for use of SuperNova v428 conjugated antibodies in a variety of flow cytometry applications
- VTi 90ロータと塩化セシウム等密度勾配超遠心法(CsCl DGUC)を用いたウイルスベクター精製
- Rapid Measurement of IgG Using Fluorescence Polarization
- Valita Titer アッセイを用いた迅速なウサギIgG定量
- Robust and High-Throughput SARS-CoV-2 Viral RNA Detection, Research, and Sequencing Using RNAdvance Viral and the OT-2 Platform
- Screening yeast extract to improve biomass production in acetic acid bacteria starter culture
- 卓上型セルソーターCytoFLEX SRTによるシングルセルソーティング
- 卓上型セルソーターCytoFLEX SRTを使用した 稀少なE-SLAM造血幹細胞のソーティングと その後の培養
- SWOFF The unrecognized yet indispensable sibling of FMO
- The scattered light signal: Calibration of biomass
- Utilization of the MicroClime Environmental Lid to Reduce Edge Effects in a Cell-based Proliferation Assay
- Vertical Rotor Case Study with Adenovirus
- Variability Analysis of the Vi-CELL BLU Cell Viability Analyzer against 3 Automated Cell Counting Devices and the Manual Method
- 超遠心分離法によるウイルスベクターの精製
- Whole Genome Sequencing of Microbial Communities for Scaling Microbiome and Metagenomic Studies Using the Echo 525 Liquid Handler and CosmosID
- Comparative Analysis of Cell-Free DNA Extraction Efficiency from Plasma
-
製品カタログ / データシート
- Access Single Robot System for Synthetic Biology Workflows
- Automated Solutions for Cell Line Development
- Automated Solutions for ELISA
- Echo Acoustic Liquid Handling for Synthetic Biology
- HIAC 8011+ Liquid Particle Counting Systems
- HIAC 9703+ による不溶性微粒子試験
- LS 13 320 XR - Laser Diffraction Particle Size Analyzer
- Download the Valita Titer Assay Brochure
-
導入事例 (インタビュー記事)
- 高速冷却遠心機を用いたアデノウイルスベクターの効率的で再現性の良い調製方法
- セルソーターを用いたバイオ燃料高産生藻のハイスループット遺伝子改変オートメーションシステム
- 老舗の培地メーカーが挑む抗体開発と培地開発
- 「細胞のごみ」を分解するオートファジーの 全容に迫る
- B細胞の生成と成熟、維持の研究を創薬にも活かす
- 生殖生物学の基礎研究と現在の生殖補助医療
- 動脈硬化の免疫的な機序から心血管疾患の治療と予後を研究 ― マルチカラーフローサイトメーターで研究を加速 ―
- 10カラーフローサイトメトリーを用いた細胞マーカー解析の有用性
- 研究に最適な卓上遠心機を選択するポイント
- 新しいアプローチでの膠原病疾患治療に向けて
- 最善の総合医療を提供し、疾病の克服と健康の増進を通じて社会に貢献する
- 機能性抗体で免疫応答を制御し、新しい治療戦略と創薬に結びつける ― 研究を加速するフローサイトメーター ―
- 炎症の観点から疾患の発症メカニズムを解明し、治療薬を創出する
- がん遺伝子パネル解析/クリニカルシーケンスにおけるFFPE組織切片からのゲノムDNA抽出の重要性
- 大学における留学生を対象とした英語による遠心機の安全教育セミナーの有用性
- 大学における共通機器室の機器管理とサポート体制について
- 超遠心法を用いたエクソソームの分離精製
- Fast, Cost-Effective and High-Throughput Solutions for DNA Assembly
- 免疫研究で漁業の未来を変える - 研究の効率を上げるフローサイトメーター -
- 高精度の迅速診断に向けて - Navios EXによる造血器腫瘍細胞の10カラー解析の導入 -
- High-throughput next-generation DNA sequencing of SARS-CoV-2 enabled by the Echo 525 Liquid Handler
- フローサイトメトリーによる造血器腫瘍解析検査の病院内実施がもたらすもの
- iPS 細胞のメカニズムと 安全で効率のよい 樹立・維持法を追究
- Leveraging acoustic and tip-based liquid handling to increase throughput of SARS-CoV-2 genome sequencing
- X線結晶構造解析のための膜タンパク質精製の基礎
- 密度勾配超遠心法による簡便な細胞小器官の分画
- 粒子間の相互作用研究から、細胞と粒子の相互作用研究へ
- 遺伝子治療ベクターの品質評価における最新事情
- 虹彩細胞からの網膜細胞再生へ ~MoFlo Astriosの役割~
- 堆積地質学の研究における粒度分布測定
- iPS 細胞由来の “ 肝臓の芽 ” の移植で重度肝疾患の治療を目指す
- Tierra Biosciences reveals major molecular discovery
- 患者の自己骨髄細胞を用いて肝硬変を治療する
- 大学の共通機器室での機器管理とサポート体制について
- University of Texas Medical Branch UTMB Workflow Comparison Study with the AQUIOS CL Flow Cytometer
- 超遠心法によるウイルス精製の基礎
- 総合カタログ
- eBook
- フライヤー
-
インタビュー記事
- フローサイトメーターを導入した経緯や導入後の現状について -順天堂大学医学部附属静岡病院-
- 水田土壌細菌の菌体計測における コールターカウンターの有用性
- 小児白血病治療における中央診断 -小児白血病グループ研究統合の中での変遷-
- 小児白血病治療における中央診断 -小児白血病中央診断の現状-
- がん微小環境の1細胞解析におけるクラウドベース解析ソフトウエア Cytobankの貢献
- iGEM 2021 Kyotoチーム : FLOWEREVER 学部生による合成生物学の社会実装に向けた技術開発
- 院内検査室におけるフローサイトメトリー検査 -国家公務員共済組合連合会 虎の門病院-
- Fundamentals of Ultracentrifugal Virus Purification
- がん抑制遺伝子p53の標的遺伝子PHLDA3の機能解析進展とAMPure XPによるDNAクリーンアッププロセスへの貢献
- がん抑制遺伝子p53の標的遺伝子PHLDA3の機能解析進展と AMPure XPによるDNAクリーンアッププロセスへの貢献
- 籔井教授の講義シリーズ:超遠心機に振り回された研究を回顧して
-
ポスター
- AMP 2019: Correlation Between Mutations Found in FFPE Tumor Tissue and Paired cfDNA Samples
- Applications of Ultracentrifugation in Purification and Characterization of Biomolecules
- Automating Genomic DNA Extraction from Whole Blood and Serum with GenFind V3 on the Biomek i7 Hybrid Genomic Workstation
- ABRF 2019: Automated Genomic DNA Extraction from Large Volume Whole Blood
- Automated library preparation for the MCI Advantage Cancer Panel at Miami Cancer Institute utilizing the Beckman Coulter Biomek i5 Span-8 NGS Workstation
- Automating Cell Line Development for Biologics
- Cellular Challenges: Taking an Aim at Cancer
- Cell-Line Engineering
- Characterizing the Light-Scatter Sensitivity of the CytoFLEX Flow Cytometer
- ASHG 2019: Comparison between Mutation Profiles of Paired Whole Blood and cfDNA Samples
- ASHG 2019: Correlation Between Mutations Found in FFPE Tumor Tissue and Paired cfDNA Samples
- AACR 2019: Isolation and Separation of DNA and RNA from a Single Tissue or Cell Culture Sample
- 細胞数をカウントする方法
- AACR 2019: Correlation between Mutations Found in FFPE Tumor Tissue and Paired cfDNA Samples
- Preparing a CytoFLEX for Nanoscale Flow Cytometry
- A Prototype CytoFLEX for High-Sensitivity, Multiparametric Nanoparticle Analysis
- AGBT 2019: A Scalable and Automatable Method for the Extraction of cfDNA
- ABRF 2019: Simultaneous DNA and RNA Extraction from Formalin-Fixed Paraffin Embedded (FFPE) Tissue
- A Complete Automation and Reagent Workflow for Analysis of cfDNA: from Plasma to Variants
- Quantification of AAV Capsid Loading Fractions: A Comparative Study
- SARS-CoV2感染応答についての標準化ドライ抗体パネルを使用したフローサイトメトリーの有用性
- 製品の取扱説明書
- プロトコル
-
ホワイトペーパー
- Centrifugation is a complete workflow solution for protein purification and protein aggregation quantification
- AUC Insights - Analysis of Protein-Protein-Interactions by Analytical Ultracentrifugation
- GMPクリーンルームの清浄度クラスと日常環境モニタリング
- AUC Insights - Assessing the quality of adeno-associated virus gene therapy vectors by sedimentation velocity analysis
- AUC Insights - Sample concentration in the Analytical Ultracentrifuge AUC and the relevance of AUC data for the mass of complexes, aggregation content and association constants
- フローサイトメトリーによる生物学的機構の解析
- USPSubvisible Particulate Matterの変更
- Changes to USP Total Organic Carbon
- AccuPlex™SARS-CoV-2標準物質キットを用いたRNAdvance Viral XP RNA抽出キットの特徴付け
- CytoFLEX Platform Flow Cytometers with IR Laser Configurations: Considerations for Red Emitting Dyes
- Evaluation of the Analytical Performance of the AQUIOS CL Flow Cytometer in a Multi-Center Study
- Hydraulic Particle Counter Sample Preparation
- ベックマン・コールター社製ウイルスRNA抽出溶解緩衝液を用いたCOVID-19疾患ウイルスSARS-CoV-2の不活化
- Liquid Biopsy Cancer Biomarkers – Current Status, Future Directions
- MET ONE 3400+ IT Implementation Guide
- Reproducibility in Flow Cytometry
- 大容量遠心の効率化
- SuperNova v428:新しいフローサイトメトリー用の高輝度蛍光色素
- ライフサイエンス分野製品 安全性データシート(SDS/MSDS)
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アプリケーションノート