分析用超遠心システム(AUC)

タンパク質複合体などの巨大分子を解析できる他の技術と比較し、分析用超遠心機(AUC)は、生分子が天然の状態で存在している溶液条件のもとで、その分子の特性解析が できます。タンパク質だけでなくそれ以外の物質の分子量や流体力学的および熱力学的な特性を証明するための、最も汎用性が高く、厳密かつ正確 な解析装置です。

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Advances in Sedimentation Analysis by Dr. Borries Demeler This presentation covers advances in sedimentation velocity (SV) analysis including methods for accurately characterizing heterogeneous systems at high resolution; approaches to extract rich information from SV experiments and techniques to measure the strength of macromolecular interactions with discrete binding models to whole boundary SV experiments in analytical ultracentrifugation.
The Use of the Analytical Ultracentrifuge to Characterize Very Large Complex Biopharmaceuticals This webinar covers the key attributes of AUC as a highly effective technique for characterizing viral vectors for viral gene therapy delivery systems
Analytical Ultracentrifugation in the Biopharmaceutical Industry Dr. Alexander Bepperling focuses on the data analysis tools to achieve high precision when analyzing biopharmaceutical products due to an interest in minor species of about 1-2% usually comprising of the total protein content. He focuses on the data analysis done in SEDFIT. Learn how to set up continuous c(S) distribution analysis as implemented with SEDFIT software for enhanced reproducibility during a study of many batches of one protein. Also covers applications of sedimentation equilibrium (SE) for screening weak interactions and determining detergent binding to proteins.
Addressing the Challenges of Purification & Quality Control in Gene Therapy Our panelists will focus on several pertinent topics in rAAV process development including current challenges, technologies for overcoming quality control hurdles, best practices for downstream processing, as well as discuss the current trends and future outlook of this rapidly growing therapeutic frontier.