質量分析法

自動化を通じた革新的な質量分析用検体調製法

プロテオミクス研究からは、限定的で変性しやすい検体物質、および分解、ダイナミックレンジの拡大、過剰な翻訳後修飾といった問題が明らかにされています。解析対象が単一タンパク質であろうとプロテオーム全体であろうと、質量分析用の検体の調製を自動化すると、再現性の向上に役立つとともに、時間と経費の削減といった利益にもつながります。

液体自動処理システムBiomekは分注機能にダイナミックレンジを備えており、質量分析法用の検体調製の一部または完全自動化設定が可能です。

Mass Spectrometry Resources

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Title Description
Automated Salt-Assisted Liquid-Liquid Extraction
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Authors: Michael Kowalski and Ruth Zhang | Beckman Coulter Life Sciences, Indianapolis, IN, USA, Yun Yun Zou and Michael Jarvis | SCIEX, Concord, ON, Canada
Automated Sample Preparation for the Monitoring of Pharmaceutical and Illicit Drugs by LC-MS/MS
{442DF88C-CA7F-4B78-AF75-9D2B985534C0}
This application note describes results obtained using a liquid handling-based automation system for the sample preparation of compounds to be analyzed by LC-MS/ MS and applied to the monitoring of multiple classes of pharmaceutical and illicit drugs.
Automating Biologics Signature Peptide Quantitation
{442DF88C-CA7F-4B78-AF75-9D2B985534C0}
Authors: Ian Moore, Technical Marketing Manager | SCIEX, Concord, Canada, Michael Kowalski, Staff Applications Scientist | Beckman Coulter Life Sciences, Indianapolis, IN
Automated Sample Preparation for the Monitoring of Ethanol Metabolites in Urine by LC-MS/MS
{442DF88C-CA7F-4B78-AF75-9D2B985534C0}
In this application note, we describe an LC-MS/MS method for the analysis of EtG and EtS in urine employing a simple, automated sample preparation methodology using a liquid handling-based automation system.
Automated Sample Preparation for Analysis of 25-OH Vitamin D3 and 25-OH-Vitamin D2 by LC/MS/MS
{442DF88C-CA7F-4B78-AF75-9D2B985534C0}
In this work, we demonstrate the feasibility of automating the sample preparation for liquid chromatography-tandem mass spectrometry (LC/MS/MS) analysis of 25-OH-Vitamin D2 and 25-OH-Vitamin D3.
Automated salt-assisted liquid-liquid extraction
{442DF88C-CA7F-4B78-AF75-9D2B985534C0}
In this work, we have utilized a Biomek NXP Workstation to automate the liquid handling steps of salt-assisted liquid-liquid extraction of 25-OH-Vitamin D from serum
Innovations that Reshape Sample Prep for Bioanalysis
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Proteomics research presents issues of limited and variable sample material and degradation, vast dynamic range and a plethora of post-translational modifications
Trends in Mass Spectrometry
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Mike Kowalski, Ph.D. compares and contrasts methods for biologics analysis, including liquid chromatography/mass spectrometry (LC/MS) and the SCIEX BioBA solution
New Automation Strategies For Improving Sample Prep - The Analytical Laboratory
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This presentation by Michael Kowalski at Beckman Coulter Life Sciences covers automation of capillary electrophoresis and mass spectrometry workflows for the analytical laboratory. Learn how the Biomek 4000 Workstation enables accurate sample prep, essential for downstream applications.


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