Echo ラーニングセンター

Better + Together. 2019年、ベックマン・コールターライフサイエンスとLabcyteが一緒になったことで、Echoリキッドハンドラーの音響分注によってもたらされるパワーとBiomek自動ワークステーションの技術が統合され、創薬、サンプルマネジメント、合成生物学、ジェノミクス、プロテオミクス、ファンクションスクリーニングなどのワークフローにおいて、複雑な液体分注にも対応できる柔軟なリキッドハンドラーという、新たなソリューションが誕生しました。

音響エネルギーによる、最小2.5 nL での高精度、非接触、自動化の微量分注機です。未体験の正確性、高効率、持続可能性をEchoアコースティック微量分注機でお確かめください。

Echo Acoustic Liquid Handlers - Beckman Coulter Life Sciences

音響による液体分注

 

Echoアコースティック微量分注機は

  • アコースティックドロップエジェクション(ADE)技術の搭載により、正確かつ高速での分注が実現(最大700ドロップ/秒)
  • Echoソースプレート(下側)から(反転させた上側の)ディスティネーションプレートへ非接触分注
  • ダイナミックフルードアナリシス(DFA)がパラメータをリアルタイム調整し、ナノリットルレベルでも信頼性の高い分注が可能(ユーザによる調整不要)
  • 各ウェル中の液体の高さを計算、溶液タイプ(DMSO等)やグリセロール濃度も分析
  • 1:1、1:複数ウェル、複数ウェル:1での分注や、ソースプレートからディスティネーションプレートのドライウェル、あるいはプレフィルドウェルなどの複雑な組み合わせ分注が可能

さらに詳しい情報はこちらから

カタログ

動画

Echoアコースティック微量分注機 製品モデル

 

Echoソフトウエア

 

Echo関連文献

  1. Bashore C et al. Targeted degradation via direct 26S proteasome recruitment. Nat Chem Biol. 2023 Jan;19(1):55-63. Epub 2022 Dec 28. PMID: 36577875
  2. Ma S et al. Transcriptional repression of estrogen receptor alpha by YAP reveals the Hippo pathway as therapeutic target for ER+ breast cancer. Nat Commun. 2022 Feb 25;13(1):1061. PMID: 35217640
  3. Pal R, Seleem MN. Discovery of a novel natural product inhibitor of Clostridioides difficile with potent activity in vitro and in vivo. PLoS One. 2022 Aug 8;17(8):e0267859. PMID: 35939437
  4. Papandreou A et al. Automated High-Content Imaging in iPSC-derived Neuronal Progenitors. SLAS Discov. 2023 Jan 4:S2472-5552(22)13715-9. PMID: 36610640
  5. Riva L et al. Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing. Nature. 2020 Oct;586(7827):113-119. Epub 2020 Jul 24. PMID: 32707573
  1. Li J et al. DRUG-seq Provides Unbiased Biological Activity Readouts for Neuroscience Drug Discovery. ACS Chem Biol. 2022 Jun 17;17(6):1401-1414. Epub 2022 May 4. PMID: 35508359
  2. Nyffeler J et al. Combining phenotypic profiling and targeted RNA-Seq reveals linkages between transcriptional perturbations and chemical effects on cell morphology: Retinoic acid as an example. Toxicol Appl Pharmacol. 2022 Jun 1;444:116032. Epub 2022 Apr 26. PMID: 35483669
  1. Bousgouni V, Bakal C. Quantitative imaging of single-cell phenotypes in cancer cells cultured on hydrogel surfaces. STAR Protoc. 2022 Dec 15;4(1):101942. doi: 10.1016/j.xpro.2022.101942. Epub ahead of print. PMID: 36525347
  2. Denisova OV et al. Development of actionable targets of multi-kinase inhibitors (AToMI) screening platform to dissect kinase targets of staurosporines in glioblastoma cells. Sci Rep. 2022 Aug 13;12(1):13796. doi: 10.1038/s41598-022-18118-7. PMID: 35963891
  3. Ross-Thriepland D et al. Arrayed CRISPR Screening Identifies Novel Targets That Enhance the Productive Delivery of mRNA by MC3-Based Lipid Nanoparticles. SLAS Discov. 2020 Jul;25(6):605-617. doi: 10.1177/2472555220925770. Epub 2020 May 22. PMID: 32441189
  1. Bashore C et al. Targeted degradation via direct 26S proteasome recruitment. Nat Chem Biol. 2023 Jan;19(1):55-63. Epub 2022 Dec 28. PMID: 36577875
  2. Ma S et al. Transcriptional repression of estrogen receptor alpha by YAP reveals the Hippo pathway as therapeutic target for ER+ breast cancer. Nat Commun. 2022 Feb 25;13(1):1061. PMID: 35217640
  3. Pal R, Seleem MN. Discovery of a novel natural product inhibitor of Clostridioides difficile with potent activity in vitro and in vivo. PLoS One. 2022 Aug 8;17(8):e0267859. PMID: 35939437
  4. Papandreou A et al. Automated High-Content Imaging in iPSC-derived Neuronal Progenitors. SLAS Discov. 2023 Jan 4:S2472-5552(22)13715-9. PMID: 36610640
  5. Riva L et al. Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing. Nature. 2020 Oct;586(7827):113-119. Epub 2020 Jul 24. PMID: 32707573
  1. Li J et al DRUG-seq Provides Unbiased Biological Activity Readouts for Neuroscience Drug Discovery. ACS Chem Biol. 2022 Jun 17;17(6):1401-1414. Epub 2022 May 4. PMID: 35508359
  2. Nyffeler J et al. Combining phenotypic profiling and targeted RNA-Seq reveals linkages between transcriptional perturbations and chemical effects on cell morphology: Retinoic acid as an example. Toxicol Appl Pharmacol. 2022 Jun 1;444:116032. Epub 2022 Apr 26. PMID: 35483669
  1. Bousgouni V, Bakal C. Quantitative imaging of single-cell phenotypes in cancer cells cultured on hydrogel surfaces. STAR Protoc. 2022 Dec 15;4(1):101942. doi: 10.1016/j.xpro.2022.101942. Epub ahead of print. PMID: 36525347
  2. Denisova OV et al. Development of actionable targets of multi-kinase inhibitors (AToMI) screening platform to dissect kinase targets of staurosporines in glioblastoma cells. Sci Rep. 2022 Aug 13;12(1):13796. doi: 10.1038/s41598-022-18118-7. PMID: 35963891
  3. Ross-Thriepland D et al. Arrayed CRISPR Screening Identifies Novel Targets That Enhance the Productive Delivery of mRNA by MC3-Based Lipid Nanoparticles. SLAS Discov. 2020 Jul;25(6):605-617. doi: 10.1177/2472555220925770. Epub 2020 May 22. PMID: 32441189

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